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Am J Perinatol
DOI: 10.1055/a-2335-2480
Original Article

Gestational Weight Gain and Neonatal Biometry during the COVID-19 Pandemic: A Multicenter Observational Cohort

Mahmoud Abdelwahab
1   Departments of Obstetrics and Gynecology of The Ohio State University, Columbus, Ohio
,
Jessica A. de Voest
2   The George Washington University Biostatistics Center, Washington, District of Columbia
,
Torri D. Metz
3   Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, Utah
,
Brenna L. Hughes
4   Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
,
William A. Grobman
5   Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois
,
George R. Saade
6   Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas
,
Tracy A. Manuck
4   Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
,
Monica Longo
7   Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland
,
Hyagriv N. Simhan
8   Department of Obstetrics and Gynecology, University of Pittsburgh, Pittsburgh, Pennsylvania
,
Dwight J. Rouse
9   Department of Obstetrics and Gynecology, Brown University, Providence, Rhode Island
,
Hector Mendez-Figueroa
10   Department of Obstetrics and Gynecology, University of Texas Health Science Center at Houston, Children's Memorial Hermann Hospital, Houston, Texas
,
Cynthia Gyamfi-Bannerman
11   Department of Obstetrics and Gynecology, Columbia University, New York, New York
,
Jennifer L. Bailit
12   Department of Obstetrics and Gynecology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio
,
Maged M. Costantine 
1   Departments of Obstetrics and Gynecology of The Ohio State University, Columbus, Ohio
,
Harish M. Sehdev
13   Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania
,
Alan T.N. Tita
14   Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama
,
for the Eunice Kennedy Shriver National Institute of Child Health Human Development Maternal-Fetal Medicine Units Network, Bethesda, MD, United States › Author Affiliations Funding This work is funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (grant nos.: UG1 HD087230, UG1 HD027869, UG1 HD027915, UG1 HD034208, UG1 HD040500, UG1 HD040485, UG1 HD053097, UG1 HD040544, UG1 HD040545, UG1 HD040560, UG1 HD040512, UG1 HD087192, and U24 HD036801) and the National Center for Advancing Translational Sciences (grant no.: UL1TR001873). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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Abstract

Objective This study aimed to test the hypothesis that being pregnant and delivering during the coronavirus disease 2019 (COVID-19) pandemic was associated with changes in gestational weight gain (GWG) or frequency of small- (SGA) or large-for-gestational-age (LGA) neonates.

Study Design Secondary analysis of a multicenter observational cohort comparing pregnant people who delivered during the COVID-19 pandemic (June–December 2020) to people who delivered prior to the pandemic (March–December 2019). Those with multiple gestations, fetuses with major congenital anomalies, implausible GWG values, unavailable body mass index (BMI), or who were severe acute respiratory syndrome coronavirus-2-positive were excluded. The primary outcome was frequency of optimal recommended GWG based on prepregnancy BMI. Neonatal outcomes included birth weight, ponderal index, and frequency of SGA, LGA, and small head circumference for live births. Multivariable regression analysis was used to assess associations between exposure to the pandemic and outcomes.

Results A total of 10,717 pregnant people were included in our analysis. A total of 4,225 pregnant people were exposed to the pandemic and 6,492 pregnant people delivered prior to the COVID-19 pandemic. Pregnant people exposed to the pandemic were older and more likely to have gestational diabetes. The frequency of appropriate GWG was 28.0% during the pandemic and 27.6% before the pandemic (adjusted odds ratio [aOR]: 1.02, 95% confidence interval [CI]: 0.93–1.11). Excessive GWG was more likely (54.9 vs. 53.1%; aOR: 1.08, 95% CI: 1.001–1.17), and inadequate GWG was less likely during the pandemic (17.0 vs. 19.3%; aOR: 0.86, 95% CI: 0.77–0.95). The frequency of SGA was 5.4% during the pandemic and 6.1% before the pandemic (aOR: 0.90, 95% CI: 0.76–1.06), and the frequency of LGA was 16.0% during the pandemic versus 15.0% before the pandemic (aOR: 1.06, 95% CI: 0.95–1.18). Other neonatal outcomes including birth weight percentile (62.1 [35.8–83.2] vs. 60.2 [34.4–82.2]; adjusted mean difference (aMD) = 1.50, 95% CI: −0.28 to 3.29), ponderal index (2.6 g/cm3 [2.4–2.8] in both groups; aMD = 0.01, 95% CI: 0.00–0.02), and small head circumference for livebirths (<10th percentile [8.2 vs. 8.1%; aOR: 1.03, 95% CI: 0.89–1.19], <3rd percentile [3.5 vs. 3.1%; aOR: 1.16, 95% CI: 0.93–1.44]) were similar between groups as well.

Conclusion Being pregnant and delivering during the COVID-19 pandemic was associated with a higher likelihood of excessive GWG and a lower likelihood of inadequate GWG.

Key Points

  • Delivering during the COVID-19 pandemic was associated with higher likelihood of excessive GWG.

  • Delivering during the COVID-19 pandemic was associated with lower likelihood of inadequate GWG.

  • COVID-19 pandemic was not associated with changes in frequency of SGA or LGA.

Keywords

COVID-19 in pregnancy - gestational weight gain - neonatal biometry - quarantine

Note

A portion of this work was presented in abstract form at the Society for Maternal Fetal Medicine 43rd Annual Pregnancy Meeting in San Francisco, California (February 6–11, 2023).


* A list of the full members of the NICHD MFMU Network is available in the Acknowledgments.




Publication History

Received: 17 December 2023

Accepted: 17 May 2024

Accepted Manuscript online:
29 May 2024

Article published online:
24 June 2024

© 2024. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 

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