Lee S,
Yu JD,
Monterde AL,
Tung SE,
Wang Y-N,
Gay BL,
Hull KL.
*
University of Texas at Austin, USA
Chemoselective Cu-Catalyzed Cross-Nucleophile Alkylarylation of Alkenes.
ACS Catal 2024;
14: 14242-14250
DOI:
10.1021/acscatal.4c03955
Keywords
alkenes - alkylarylation - boronic acids - cross-nucleophile coupling - 1,1-diarylalkanes
Significance
Hull and co-workers report an oxidative cross-nucleophile strategy for the alkylarylation
of vinyl arenes using two different boronic acids. This operationally simple and scalable
protocol provides straightforward access to 1,1-diarylalkanes.
Comment
Mechanistic investigations support the shown mechanism. Lewis pair formation of the
in situ formed boroxines and the added amine was found to be crucial for this transformation
(see gray box).
