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Klin Monbl Augenheilkd 2024; 241(12): 1302-1308
DOI: 10.1055/a-2453-8253
Experimentelle Studie

In Vivo Acquisition of Human Retinal Double-Pass Images during Simulated Intraocular Lens Implantation

In-vivo-Abbildung humaner retinaler Doppel-Pass-Bilder bei simulierter Implantation von Intraokularlinsen
Karsten Sperlich 
1   Department of Ophthalmology, Rostock University Medical Center, Rostock, Germany
2   Department Life, Light & Matter, University of Rostock, Germany
,
Sebastian Bohn
1   Department of Ophthalmology, Rostock University Medical Center, Rostock, Germany
2   Department Life, Light & Matter, University of Rostock, Germany
,
Mario Gerlach
3   Innovation Optics, Carl Zeiss Meditec AG, Berlin, Germany
,
Julia Schubert
1   Department of Ophthalmology, Rostock University Medical Center, Rostock, Germany
,
Heinrich Stolz
4   Institute of Physics, University of Rostock, Germany
,
Rudolf Guthoff
1   Department of Ophthalmology, Rostock University Medical Center, Rostock, Germany
2   Department Life, Light & Matter, University of Rostock, Germany
,
Oliver Stachs
1   Department of Ophthalmology, Rostock University Medical Center, Rostock, Germany
2   Department Life, Light & Matter, University of Rostock, Germany
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Abstract

Background The aim of the study was to capture images that form on the human retina after the simulated implantation of an intraocular lens (IOL). White light was used rather than the commonly used near-infrared light, which is unsuitable for the examination of diffractive IOLs. For this purpose, a special optical setup was developed to investigate the influence of the IOL design on two-dimensional retinal images in vivo.

Materials and Methods A double-pass ophthalmoscopic setup with a scientific CCD camera system was developed. Imaging the retinal image of a white LED located at infinity provides access to the double-pass point spread function of the natural eye. Subsequently, a see-through device for simulated IOL implantation (VirtIOL, 10Lens S. L. U., Terrassa, Spain) was integrated to investigate the influence of the IOL design on the retinal image quality of complex scenarios.

Results Retinal images were acquired from an incoherent white point light source. Combined with simulated IOL implantation, retinal images were acquired from the point light source, letters, and a United States Airforce target on a 6-m distant monitor. As expected, the double-pass images obtained with a monofocal IOL were sharper than those obtained with a multifocal IOL.

Conclusion The method opens up access to double-pass point spread function for white light, thus solving the problem of infrared light-based methods providing incorrect results when examining diffractive IOLs. This approach may be helpful for the investigation of perception in the future.

Zusammenfassung

Hintergrund Ziel der Studie war es, Bilder zu erfassen, die sich nach der simulierten Implantation einer Intraokularlinse (IOL) auf der menschlichen Netzhaut formen. Hierbei wurde weißes Licht verwendet und nicht das üblicherweise genutzte nahinfrarote Licht, das für die Untersuchung von diffraktiven IOLs ungeeignet ist. Dazu wurde ein spezieller optischer Aufbau entwickelt, um den Einfluss des IOL-Designs auf 2-dimensionale Netzhautbilder in vivo zu untersuchen.

Material und Methode Es wurde ophthalmoskopischer Doppel-Pass-Aufbau mit einem wissenschaftlichen CCD-Kamerasystem entwickelt. Die Abbildung des Netzhautbildes einer im Unendlichen befindlichen weißen LED bietet den Zugang zur Doppel-Pass-Punktspreizfunktion des natürlichen Auges. Anschließend wurde ein Durchsichtgerät zur simulierten IOL-Implantation (VirtIOL, 10Lens S. L. U., Terrassa, Spanien) integriert, um den Einfluss des IOL-Designs auf die retinale Bildqualität komplexer Szenarien zu untersuchen.

Ergebnisse Es wurden Netzhautbilder von einer inkohärenten weißen Punktlichtquelle aufgenommen. Kombiniert mit simulierter IOL-Implantation wurden retinale Bilder von einer Punktlichtquelle und Buchstaben oder USAF target auf einem 6 m entfernten Monitors aufgenommen. Erwartungsgemäß waren die Doppel-Pass-Bilder, welche mit einer monofokalen IOL aufgenommen wurden, schärfer als jene mit einer multifokalen IOL.

Schlussfolgerung Die Methodik öffnet den Zugang zur Doppel-Pass-PSF für weißes Licht und löst damit das Problem, dass infrarotlichtbasierte Methoden im Fall der Untersuchung von diffraktiven IOLs falsche Ergebnisse liefern. Der Ansatz kann perspektivisch für die Untersuchung der Wahrnehmung hilfreich sein.

Keywords

cataract - intraocular lens - point spread function - double-pass imaging - simulated implantation - retinal image

Schlüsselwörter

Katarakt - Intraokularlinse - Punktspreizfunktion - Doppel-Pass-Bildgebung - simulierte Implantation - retinales Bild


Publication History

Received: 13 June 2024

Accepted: 23 October 2024

Article published online:
05 December 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany

 

  • References

  • 1 Flamant F. Étude de la répartition de lumière dans lʼimage rétinienne dʼune fente [Study of light distribution in the retinal image of a slit]. Rev Opt Theor Instrum 1955; 34: 433-459
    PubMedSearch in Google Scholar
  • 2 Demott DW. Direct measures of the retinal image. J Opt Soc Am 1959; 49: 571-579
    CrossrefPubMedSearch in Google Scholar
  • 3 Westheimer G, Campbell FW. Light distribution in the image formed by the living human eye. J Opt Soc Am 1952; 52: 1040-1045
    CrossrefPubMedSearch in Google Scholar
  • 4 Krauskopf J. Light distribution in human retinal images. J Opt Soc Am 1962; 52: 1046-1050
    CrossrefPubMedSearch in Google Scholar
  • 5 Walsh G, Charman WN, Howland HC. Objective technique for the determination of monochromatic aberrations of the human eye. J Opt Soc Am A 1984; 1: 987-992
    CrossrefPubMedSearch in Google Scholar
  • 6 Arnulf A, Santamaria J, Bescos J. A cinematographic method for the dynamic study of the image formation by the human eye. Microfluctuations of the accommodation. J Opt 1981; 12: 123-128
    CrossrefPubMedSearch in Google Scholar
  • 7 Santamaria J, Artal P, Bescos J. Determination of the point-spread function of human eyes using a hybrid optical-digital method. J Opt Soc Am A 1986; 4: 1109-1114
    CrossrefPubMedSearch in Google Scholar
  • 8 Artal P, Santamaría J, Bescós J. Optical-digital procedure for the determination of white-light retinal images of a point test. Opt Eng 1989; 28: 687-690
    CrossrefPubMedSearch in Google Scholar
  • 9 Artal P, Iglesias I, López-Gil N. et al. Double-pass measurements of the retinal-image quality with unequal entrance and exit pupil sizes and the reversibility of the eyeʼs optical system. J Opt Soc Am A 1995; 12: 2358-2366
    CrossrefPubMedSearch in Google Scholar
  • 10 López-Gil N, Iglesias I, Artal P. Retinal image quality in the human eye as a function of the accommodation. Vision Res 1998; 38: 2897-2907
    CrossrefPubMedSearch in Google Scholar
  • 11 López-Gil N, Artal P. Comparison of double-pass estimates of the retinal-image quality obtained with green and near-infrared light. J Opt Soc Am A 1997; 14: 961-971
    CrossrefPubMedSearch in Google Scholar
  • 12 Gatinel D. Double pass–technique limitations for evaluation of optical performance after diffractive IOL implantation. J Cataract Refract Surg 2011; 37: 621-622
    CrossrefPubMedSearch in Google Scholar
  • 13 Vega F, Millán MS, Vila-Terricabras N. et al. Visible Versus Near-Infrared Optical Performance of Diffractive Multifocal Intraocular Lenses. Invest Ophthalmol Vis Sci 2015; 56: 7345-7351
    CrossrefPubMedSearch in Google Scholar
  • 14 Charman WN, Montés-Micó R, Radhakrishnan H. Can we measure wave aberration in patients with diffractive IOLs?. J Cataract Refract Surg 2007; 33: 1997
    CrossrefPubMedSearch in Google Scholar
  • 15 Charman W, Montés-Micó R, Radhakrishnan H. Problems in the measurement of wavefront aberration for eyes implanted with diffractive bifocal and multifocal intraocular lenses. J Refract Surg 2008; 24: 280-286
    CrossrefPubMedSearch in Google Scholar
  • 16 Elsner R, Gerlach M, Bohn S. et al. On the misconception of using near-infrared light in clinical evaluations of diffractive intraocular lenses – a chromatic analysis. Biomed Opt Express; 2024. (submitted)
    Search in Google Scholar
  • 17 International Commission on Non-Ionizing Radiation Protection. ICNIRP Guidelines on Limits of Exposure to Incoherent Visible and Infrared Radiation. Health Phys 2013; 105: 74-96
    CrossrefPubMedSearch in Google Scholar
  • 18 Gerlach M, Guthoff RF, Stachs O. et al. Präklinische Bewertung von Intraokularlinsen durch simulierte Implantation. Klin Monbl Augenheilkd 2018; 235: 1332-1341
    Thieme ConnectPubMedSearch in Google Scholar
  • 19 Khurana AK. Theory and Practice of Optics and Refraction. 2nd ed.. ed. New Dehli, India: Elsevier India; 2008: 32-34
    Search in Google Scholar
  • 20 Lang GK, Lange GE. Augenheilkunde essentials. Stuttgart: Thieme; 2015: 21-22
    Search in Google Scholar