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Synthesis 2025; 57(04): 800-811
DOI: 10.1055/a-2464-6964
DOI: 10.1055/a-2464-6964
paper
Facile Synthesis of 2- and 3-Substituted Indoles Using a Catalytic Amount of Pd/C and 1-Octene System
The work was supported by the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan.

Abstract
A novel and efficient synthesis of 3- and 2-substituted indoles starting from 2-(2-nitro-1-phenylethyl or 2-nitro-1-alkyl)cyclohexanones and 1,4-diketones, respectively, using a catalytic amount of Pd/C and 1-octene system is reported.
Key words
2- and 3- substituted indoles - Pd/C - 1-octene - one-pot synthesis - nitrone - 5-keto nitroalkanes - 1,4-diketone - ammonium acetateSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2464-6964.
- Supporting Information
Publikationsverlauf
Eingereicht: 02. September 2024
Angenommen nach Revision: 08. November 2024
Accepted Manuscript online:
08. November 2024
Artikel online veröffentlicht:
05. Dezember 2024
© 2024. Thieme. All rights reserved
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For reviews on indole nucleus in natural products with biological activities, see:
For reviews on indole synthesis, see: