Synthesis 2025; 57(04): 800-811
DOI: 10.1055/a-2464-6964
paper

Facile Synthesis of 2- and 3-Substituted Indoles Using a Catalytic Amount of Pd/C and 1-Octene System

Xu Dong
,
Ryosuke Matsubara
,
Masahiko Hayashi
The work was supported by the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan.


Abstract

A novel and efficient synthesis of 3- and 2-substituted indoles starting from 2-(2-nitro-1-phenylethyl or 2-nitro-1-alkyl)cyclohexanones and 1,4-diketones, respectively, using a catalytic amount of Pd/C and 1-octene system is reported.

Supporting Information



Publikationsverlauf

Eingereicht: 02. September 2024

Angenommen nach Revision: 08. November 2024

Accepted Manuscript online:
08. November 2024

Artikel online veröffentlicht:
05. Dezember 2024

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