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Synfacts 2025; 21(01): 19
DOI: 10.1055/a-2467-4943
Synthesis of Materials and Unnatural Products

Click-Clip

Contributor(s):
Dahui Zhao
,
Chen Li
Zhao J, Yu H, Jin X, Qin B, Mei S, Xu J-F, * Zhang X. Tsinghua University, Beijing, P. R. China
Radical-Mediated Click-Clip Reactions.

Science 2024;
385: 1354-1359
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Keywords

click reaction - clip reaction - radical reaction - quantitative reaction

Significance

Click reactions are renowned for their high efficiency, rapid kinetics, and good selectivity. Not surprisingly, it is generally difficult to reverse click reactions, because they typically have much favored thermodynamics. Here, a reversible, radical-mediated click reaction is developed.


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Comment

By developing and applying a set of highly effective redox conditions, rapid and quantitative ‘click-clip’ reactions are realized by reversibly coupling phenothiazines with amines to form sulfilimines.


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Publication History

Article published online:
20 December 2024

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