Iorga B,
Campagne J-M *.
ICSN-CNRS, France
Ethyl Propiolate: A Simple and Convenient Peptide Coupling Reagent.
Synlett 2004;
10: 1826-1828
DOI:
10.1055/s-2004-829553
Keywords
ethyl propiolate - peptide synthesis - coupling reagent
Significance
The development of practical, handy, commercially available, inexpensive, and sustainable reagents for peptide synthesis has gained significant attention in organic synthesis. In this paper, the authors used ethyl propiolate as an efficient coupling reagent for peptide synthesis.
Comment
Ethyl propiolate mediated peptide coupling between N-protected amino acids and amino acid esters proceeded smoothly to deliver the desired dipeptides in good yields. This method is simple to carry out, and inexpensive commercially available ethyl propiolate was used for the reaction.
