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Synfacts 2025; 21(01): 95
DOI: 10.1055/a-2467-6245
Peptide Chemistry

Electrochemical Ring-Opening Reaction of Piperidine-Containing Peptides

Contributor(s):
Hisashi Yamamoto
,
Tomohiro Hattori 
Fang X, Zeng Y, Huang Y, Zhu Z, Lin S, Xu W, Zheng C, Hu X *, Qiu Y *, Ruan Z *. Guangzhou Medical University and Nankai University, Tianjin, P. R. China
Electrochemical Synthesis of Peptide Aldehydes via C–N Bond Cleavage of Cyclic Amines.

Nat. Commun. 2024;
15: 5181
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Keywords

electrochemical reaction - piperidines - ring-opening reaction

Significance

Given the increasing demand for peptides, new methods for the preparation of unnatural amino acids with various active functional groups are strongly desired. Here, the authors have developed an electrochemical synthesis of peptides with an aldehyde group.


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Comment

The electrochemical reaction proceeded via cleavage of the C–N bond of the piperidine unit and gave the corresponding peptide with an aldehyde side chain. The method could be applied for pentapeptides.


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Publication History

Article published online:
20 December 2024

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