A Manganese-Catalyzed Knorr Pyrrole Synthesis

Keywords

amino alcohols - dehydrogenative coupling - Knorr pyrrole synthesis - manganese catalysis - pyrroles

Significance

Kempe and co-workers disclosed a catalytic protocol for the Knorr pyrrole synthesis from 1,2-amino alcohols and β-keto esters under dehydrogenative coupling using a manganese catalyst. This method enables access to highly functionalized pyrroles in good to high yields.

Comment

NMR spectroscopic studies and control experiments support the shown mechanism. The catalytic protocol is also applicable for the synthesis of pyridines using 1,3-amino alcohols and β-keto esters via dihydropyridine intermediates (not shown).

Publication History

Article published online:
28 January 2025