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Synfacts 2008(11): 1212-1212
DOI: 10.1055/s-0028-1083455
DOI: 10.1055/s-0028-1083455
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Simple Conversion of Esters to Primary Amides Using Magnesium Nitride
G. E. Veitch, K. L. Bridgwood, S. V. Ley*
University of Cambridge, UK
Further Information
Publication History
Publication Date:
23 October 2008 (online)
Significance
A direct conversion of esters to primary amides is relatively difficult to perform, and, usually, a complicated three-step sequence is required to effect this transformation. The use of readily available and easy-to-handle magnesium nitride offers an elegant and quite convenient one-step solution for this problem. The reaction gives good yields even with difficult substrates like tert-butyl α,β-unsaturated esters.