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Synfacts 2008(11): 1202-1202
DOI: 10.1055/s-0028-1083456
DOI: 10.1055/s-0028-1083456
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New YorkDirect Pd-Catalyzed Acylation of Aryl Bromides with Aldehydes
J. Ruan, O. Saidi, J. A. Iggo, J. Xiao*
University of Liverpool, UK
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
23. Oktober 2008 (online)

Significance
Aryl alkyl ketones are among the most important intermediates in chemical industry. The main preparation method, the Friedel-Crafts acylation, is rather limited in substrate scope. The authors disclose herein a simple, efficient and versatile method for the preparation of these compounds starting from aryl and heteroaryl bromides and aldehydes. The protocol is easy to perform, does not require expensive ligands and allows using highly functionalized substrates.