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Synfacts 2008(11): 1203-1203
DOI: 10.1055/s-0028-1083457
DOI: 10.1055/s-0028-1083457
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Cu(I)-Promoted Synthesis of Chloromethyl Ketones from CCl3-Carbinols
R. N. Ram*, T. P. Manoj
Indian Institute of Technology, Delhi, India
Further Information
Publication History
Publication Date:
23 October 2008 (online)
Significance
Chloromethyl ketones are important synthetic intermediates, especially for the preparation of heterocycles. The present work describes a very simple, versatile, efficient and inexpensive protocol for the preparation of chloromethyl ketones starting from readily available trichlormethyl carbinols. The chloromethyl ketones, difficult to prepare by other routes, can be easily synthesized. The method should be easy to scale up and suitable for industrial use.