Synthesis of Functionalized Lactones with Heterogeneous Gold
Catalyst

F. Neau; Z. Li; R. Richards; P. Y. Toullec; J.-P. Genêt; K. Dumbuya; [nl]J. M. Gottfried; H.-P. Steinrück; V. I. Pârvulescu; V. Michelet

doi:10.1055/s-0028-1087246

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Synfacts 2009(1): 0114-0114
DOI: 10.1055/s-0028-1087246

Polymer-Supported Synthesis

Synthesis of Functionalized Lactones with Heterogeneous Gold Catalyst

Contributor(s): Yasuhiro Uozumi, Go Hamasaka
F. Neau, Z. Li, R. Richards, P. Y. Toullec, J.-P. Genêt, K. Dumbuya, J. M. Gottfried*, H.-P. Steinrück, V. I. Pârvulescu*, V. Michelet*
University of Bucharest, Romania; Colorado School of Mines, Golden, USA; École Nationale Supérieure de Chimie de Paris, France; Universität Erlangen-Nürnberg, Germany

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Publication History

Publication Date:
18 December 2008 (online)

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Significance

A gold catalyst supported on zeolite (Au/beta-NH₄ ⁺) was prepared by treatment of zeolite beta-NH₄ ⁺ with HAuCl₄ in the presence of NaOH (pH = 8.5). The intramolecular cycloisomerization of γ-acetylenic carboxylic acid 1 was carried out with Au/beta-NH₄ ⁺ (1.5 mol% Au) to give the corresponding γ-lactones 2 in 25-99% yield (7 examples).