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Synfacts 2009(1): 0037-0037  
DOI: 10.1055/s-0028-1087260
Synthesis of Materials and Unnatural Products
© Georg Thieme Verlag Stuttgart ˙ New York

Degradable Dendrimers

Contributor(s): Timothy M. Swager, Jeewoo Lim
A. M. Balija, R. E. Kohman, S. C. Zimmerman*
University of Illinois at Urbana-Champaign, USA
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Publication History

Publication Date:
18 December 2008 (online)

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Significance

The syntheses of various building blocks containing triazaadamantyl (TAA) units, including dendrimer 1, are reported. The TAA units can undergo hydrolysis under physiological conditions to its respective aldehyde and tris(amino­methyl) components. In case of 1, which is non-toxic, the hydrolysis products are also non-toxic, allowing a possible application in drug delivery.