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Synfacts 2009(1): 0045-0045  
DOI: 10.1055/s-0028-1087409
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Iridium-Catalyzed Hydrogenation of Enones

Contributor(s): Mark Lautens, Jane Panteleev
S.-M. Lu, C. Bolm*
RWTH Aachen, Germany
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Publication History

Publication Date:
18 December 2008 (online)

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Significance

The authors report an asymmetric hydrogenation of enones through iridium catalysis. The demonstrated scope extends over acyclic enones, a difficult target in asymmetric hydrogenation. The catalytic system used also worked on exo-cyclic enones.

Review: S. J. Roseblade, A. Pfaltz. Acc. Chem. Res. 2007, 40, 1402-1411.