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Synfacts 2009(1): 0057-0057
DOI: 10.1055/s-0028-1087437
DOI: 10.1055/s-0028-1087437
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Zinc-Catalyzed Conjugate Radical Addition of Phosphoric Enones
S. Lee, S. Kim*
Korea Advanced institute of Science and Technology, Deajeon, Korea
Further Information
Publication History
Publication Date:
18 December 2008 (online)
Significance
This publication describes the enantioselective radical conjugate addition of α-phosphoric enone templates by the zinc-bisoxazoline complex. Moreover, when allyltributylstannane was used as the radical trapping agent, the allylation products were obtained with high diastereo- and enantioselectivities. A tetrahedral transition state was proposed to explain the facial selectivity.