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Synfacts 2009(1): 0089-0089
DOI: 10.1055/s-0028-1087448
DOI: 10.1055/s-0028-1087448
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Cross-Coupling Reactions with Enol Phosphinates
J. Guo, J. D. Harling, P. G. Steel*, T. M. Woods
University of Durham and GlaxoSmithKline, Herts, UK
Further Information
Publication History
Publication Date:
18 December 2008 (online)
![](https://www.thieme-connect.de/media/synfacts/200901/lookinside/thumbnails/10.1055-s-0028-1087448-1.jpg)
Significance
This is the first report of the use of enol phosphinates as electrophiles in cross-coupling reactions. The authors present an interesting alternative to the conventional chemistry of enol triflates and phosphates, which are often not sufficiently stable. The Suzuki and Stille reactions proceed fairly well with these new electrophiles, giving reasonable yields of products.