Direct Synthesis of Primary Amines from Alcohols and Ammonia

C. Gunanathan; D. Milstein

doi:10.1055/s-0028-1087453

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Synfacts 2009(1): 0079-0079
DOI: 10.1055/s-0028-1087453

Metal-Mediated Synthesis

Direct Synthesis of Primary Amines from Alcohols and Ammonia

Contributor(s): Paul Knochel, Tobias Thaler
C. Gunanathan, D. Milstein*
Weizmann Institute of Science, Rehovot, Israel

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Publication History

Publication Date:
18 December 2008 (online)

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Significance

A direct, highly atom-economical and selective synthesis of primary amines from alcohols and ammonia via catalysis by a novel Ru-pincer complex has been disclosed. It can be efficiently carried out ”on water". Water-soluble alcohols, however, are best converted using toluene as solvent.