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Synfacts 2009(1): 0082-0082
DOI: 10.1055/s-0028-1087455
DOI: 10.1055/s-0028-1087455
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Trichlorosilane-Mediated Conjugate Reduction and Reductive Aldol Reaction
M. Sugiura*, N. Sato, S. Kotani, M. Nakajima*
Kumamoto University, Japan
Further Information
Publication History
Publication Date:
18 December 2008 (online)
Significance
Both conjugate reduction and reductive aldol reactions on α,β-unsaturated ketones were successfully carried out using trichlorosilane in combination with a Lewis base. The trichlorosilane-mediated reduction of the ketone proceeds selectively leading to the 1,4-reduction product.