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Synfacts 2009(3): 0236-0236  
DOI: 10.1055/s-0028-1087696
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Formal Synthesis of Platencin

Contributor(s): Philip Kocienski, Zofia Komsta
D. C. J. Waalboer, M. C. Schaapman, F. L. van Delft, F. P. J. T. Rutjes*
Radboud University Nijmegen, The Netherlands
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Publication History

Publication Date:
19 February 2009 (online)

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Significance

The focal step of the synthesis is a high pressure activated Diels-Alder reaction (A → D). For a total synthesis of Platencin see: K. C. Nicolau, G. S. Tria, D. J. Edmonds Angew. Chem. Int. Ed. 2008, 47, 1780.