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Synfacts 2009(4): 0459-0459  
DOI: 10.1055/s-0028-1087862
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Pd/HP20-Catalyzed Hydrogenation and Suzuki-Miyaura Coupling

Contributor(s): Yasuhiro Uozumi, Yoshinori Hirai
Y. Monguchi, Y. Fujita, K. Endo, S. Takao, M. Yoshimura, Y. Takagi, T. Maegawa, H. Sajiki*
Gifu Pharmaceutical University and N.E. Chemcat Corporation, Shizuoka, Japan
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Publication History

Publication Date:
23 March 2009 (online)

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Significance

Palladium on DIAION® HP20 (Pd/HP20) was prepared by mixing Pd(OAc)2 and ­DIAION® HP20 in MeOH at room temperature ­under argon atmosphere for four days (eq. 1). Pd/HP20 catalyzes the hydrogenolysis of N-benzyl-oxycarbonyl and benzyl groups, the hydro-genation of alkyne and nitro groups, etc. (eq. 2). Pd/HP20 was also applied to the Suzuki-Miyaura coupling of aryl bromides and arylboronic acids to give the corresponding biaryl compounds (eq. 3).