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Synfacts 2009(4): 0419-0419
DOI: 10.1055/s-0028-1087871
DOI: 10.1055/s-0028-1087871
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Rhodium/Me-CATPHOS-Catalyzed Hydrogenation
S. Doherty*, C. H. Smyth*, A. Harriman, R. W. Harrington, W. Clegg
Newcastle University, UK
Further Information
Publication History
Publication Date:
23 March 2009 (online)
Significance
The novel atropos enantiopure 1,3-butadiene-bridged diphosphine ligand is prepared in a very short and efficient way. The performance of this ligand is better than BINAP and other phosphine ligands for a couple of rhodium-catalyzed hydrogenation reactions of dehydroamino acid derivatives.