Download PDF
Synfacts 2009(4): 0401-0401  
DOI: 10.1055/s-0028-1087901
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Palladium-Catalyzed Asymmetric Reductive Amination of Ketones

Contributor(s): Mark Lautens, Jacki Kitching
L. Rubio-Pérez*, F. J. Pérez-Flores, P. Sharma, L. Velasco, A. Cabrera
Universidad Nacional Autónoma de México, México
Further Information

Publication History

Publication Date:
23 March 2009 (online)

    Permissions and Reprints

Significance

In recent years, asymmetric reductive amination chemistry has attracted considerable interest. In the present paper, the palladium-catalyzed asymmetric reductive amination of ketones is described. Using preformed chiral palladium complexes the target amines can be obtained in high yield and with good enantioselectivity. It is reported that under these reaction conditions reduction of the ketones to the corresponding alcohols is not observed.

Reviews: R. P. Tripathi, S. S. Verma, J. Pandey, V. K. Tiwari Curr. Org. Chem. 2008, 12, 1093-1115; I. Aillaud, J. Collin, J. Hannedouche, E. Schulz Dalton Trans. 2007, 5105-5118; T. Vilaivan, W. Bhanthumnavin, Y. Sritana-Anant Curr. Org. Chem. 2005, 9, 1315-1392.