Synthesis of Haterumalide NC

J. M. Schomaker; B. Borhan

doi:10.1055/s-0028-1088087

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Synfacts 2009(4): 0362-0362
DOI: 10.1055/s-0028-1088087

Synthesis of Natural Products and Potential Drugs

Synthesis of Haterumalide NC

Contributor(s): Philip Kocienski, Stewart Eccles
J. M. Schomaker, B. Borhan*
Michigan State University, East Lansing, USA

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Publication History

Publication Date:
23 March 2009 (online)

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Significance

Haterumalide NC is a cytotoxin isolated from an Okinawan sea sponge of the species Ircina. The synthesis depicted hinges on a macrocyclization (I → J) of a chlorovinylidene chromium carbenoid.