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Synfacts 2009(4): 0364-0364  
DOI: 10.1055/s-0028-1088094
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Ventricosene

Contributor(s): Philip Kocienski, Zofia Komsta
S. G. Sethofer, S. T. Staben, O. Y. Hung, F. D. Toste*
University of California, Berkeley, USA
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Publication History

Publication Date:
23 March 2009 (online)

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Significance

Ventricosene is a sesquiterpenoid isolated from liverwort Lophozia ventricosa. The focal step of the synthesis is a gold(I)-catalyzed cyclopropanol cycloisomerization (D → F).