Synthesis of Amphidinolides B1 and B2

doi:10.1055/s-0028-1088166

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Synfacts 2009(5): 0474-0474
DOI: 10.1055/s-0028-1088166

Synthesis of Natural Products and Potential Drugs

Synthesis of Amphidinolides B₁ and B₂

Contributor(s): Philip Kocienski, Zofia Komsta
L. Lu, W. Zhang, R. G. Carter*
Oregon State University, Corvallis, USA

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Publikationsverlauf

Publikationsdatum:
22. April 2009 (online)

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Significance

Amphidinolides B₁ and B₂ possess cytotoxic activity against certain cancer lines. This first total synthesis of amphidinolides B₁ and B₂ focuses on the aldol condensation of fragments F and G. For a correction to the article see: J. Am. Chem. Soc. 2008, 130, 11834.