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Synfacts 2009(5): 0551-0551  
DOI: 10.1055/s-0028-1088188
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Norbornadiene as an Acetylene Synthon in Palladium-Catalyzed Annulation Reactions

Contributor(s): Paul Knochel, Andreas J. Wagner
P. Thansandote, D. G. Hulcoop, M. Langer, M. Lautens*
University of Toronto, Canada
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Publication History

Publication Date:
22 April 2009 (online)

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Significance

A general procedure for the palla­dium-catalyzed annulation of halo-substituted anilines and benzamides is presented. The scope of the reaction is large and its functional group tolerance is high. The cyclic products are generally afforded in moderate (isoquinolinones) to very good yields (indoles).