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Synfacts 2009(6): 0584-0584  
DOI: 10.1055/s-0029-1216667
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Agelastatin A

Contributor(s): Philip Kocienski, Stewart Eccles
T. Yoshimitsu*, T. Ino, T. Tanaka*
Osaka University, Japan
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Publikationsverlauf

Publikationsdatum:
25. Mai 2009 (online)

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Significance

The tetracyclic oroidin alkaloid (-)-agelastatin A was isolated from the sponge Agelas dendromorpha. The natural product inhibits cancer cell growth and glycogen synthase kinase 3β. Noteworthy is the authors’ use of azides to effectively trans-diaminate a double bond (F → H).