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Synfacts 2009(6): 0677-0677  
DOI: 10.1055/s-0029-1216767
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart ˙ New York

The 1,2,4-Triazole Anion as an Acyl Transfer Catalyst

Contributor(s): Benjamin List, Kristina Zumbansen
X. Yang, V. B. Birman
Washington University, St. Louis, USA
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Publication History

Publication Date:
25 May 2009 (online)

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Significance

Yang and Birman report that the 1,2,4-triazole anion is an acyl transfer catalyst. The acetylation proved to be effective for amines, alcohols and oxazolidinones. This catalyst is also suitable for transesterification as well as for amino­lysis, where unactivated esters can be transformed into the corresponding products. Mechanistic alternatives have been investigated.