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Synthesis 2010(3): 447-452  
DOI: 10.1055/s-0029-1217111
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© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of 1,4-Disubstituted 1,2,3-Triazoles by Use of Copper(I) and Amino Acids Ionic Liquid Catalytic System

Jincan Yana, Lei Wang*a,b
a Department of Chemistry, Huaibei Coal Teachers College, Huaibei, Anhui 235000, P. R. of China
b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. of China
Fax: +86(561)3090518; e-Mail: leiwang@hbcnc.edu.cn;
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Publication History

Received 17 August 2009
Publication Date:
06 November 2009 (online)

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Abstract

An efficient and green one-pot synthesis of 1,4-disubstituted 1,2,3-triazoles from aryl iodides and alkyl chlorides, sodium azide, and terminal alkynes catalyzed by copper(I) and amino acid ionic liquid (AAIL) in [BMIM]BF4 was developed. The reactions proceeded smoothly to generate the corresponding products in high yields. In addition, CuI, AAIL, and [BMIM]BF4 could be recovered for six consecutive trials without significant loss of activity.

Key words

click reaction - triazoles - ionic liquids - amino acid - copper