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Synfacts 2009(6): 0634-0634  
DOI: 10.1055/s-0029-1217196
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Catalytic Enantioselective Synthesis of Propargylic Alcohols

Contributor(s): Hisashi Yamamoto, Zhi Li
J.-C. Zhong, S.-C. Hou, Q.-H. Bian, M.-M. Yin, R.-S. Na, B. Zheng, Z.-Y. Li, S.-Z. Liu*, M. Wang*
China Agricultural University, Beijing, P. R. of China
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Publikationsdatum:
25. Mai 2009 (online)

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Significance

A cis-cyclopropane-based amino alcohol was used as catalyst in dimethylzinc-­mediated addition of phenylacetylene and methyl propiolate to aldehydes. With aromatic aldehydes high enantioselectivities of propargylic alcohols were achieved. Aliphatic aldehydes provided less enantioselective products.