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Synfacts 2009(7): 0809-0809  
DOI: 10.1055/s-0029-1217229
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Carbonylative Suzuki-Miyaura Coupling with MCM-41/Pd(II) Complex

Contributor(s): Yasuhiro Uozumi, Tsubasa Muto
M. Cai*, G. Zheng, L. Zha, J. Peng
Jiangxi Normal University, Nanchang, P. R. of China
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Publication History

Publication Date:
22 June 2009 (online)

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Significance

The MCM-41-supported bidentate phosphine palladium(II) complex [MCM-41-2P-Pd(II)] catalyzed carbonylative Suzuki-Miyaura cross-coupling of aryl iodides 1 with arylboronic acid 3 under carbon monoxide (1 atm) to give the corresponding ketones 4 in 67-90% yield (25 examples). The catalyst was readily removed from the reaction mixture by simple filtration and was reused ten times without significant loss of activity (the formation of 4b, 1st use: 90% yield, 10th use: 88% yield, 1st to 10th average: 89% yield).