Synthesis of Bottromycin A2

H. Shimamura; H. Gouda; K. Nagai; T. Hirose; M. Ichioka; Y. Furuya; Y. Kobayashi; S. Hirono; T. Sunazuka; S. Õmura

doi:10.1055/s-0029-1217238

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Synfacts 2009(7): 0699-0699
DOI: 10.1055/s-0029-1217238

Synthesis of Natural Products and Potential Drugs

Synthesis of Bottromycin A₂

Contributor(s): Philip Kocienski
H. Shimamura, H. Gouda, K. Nagai, T. Hirose, M. Ichioka, Y. Furuya, Y. Kobayashi, S. Hirono, T. Sunazuka*, S. Õmura*
Kitasato University, Tokyo, Japan

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Publication History

Publication Date:
22 June 2009 (online)

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Significance

Bottromycin is an antibiotic against methicillin-resistant staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). It has a novel mode of action: it inhibits bacterial protein synthesis by blocking the binding of aminoacyl-tRNA to the A site on the 50S ribosome. No cross resistance to existing drugs has been observed.