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Synfacts 2009(7): 0711-0711  
DOI: 10.1055/s-0029-1217251
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Ushikulide A

Contributor(s): Philip Kocienski, Zofia Komsta
B. M. Trost*, B. M. O’Boyle
Stanford University, USA
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Publication History

Publication Date:
22 June 2009 (online)

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Significance

Ushikulide A was isolated from a culture broth of Streptomyces sp. IUK-102 and exhibits potent immunosuppressant activity. A markworthy step of this synthesis is the gold(I)-catalyzed formation of a spiroketal (E → F).