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Synfacts 2009(9): 0940-0940
DOI: 10.1055/s-0029-1217611
DOI: 10.1055/s-0029-1217611
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of a Polychlorinated Sulpholipid Cytotoxin
C. Nilewski, R. W. Geisser, E. M. Carreira*
ETH Zürich, Switzerland
Further Information
Publication History
Publication Date:
21 August 2009 (online)
Significance
The polychlorinated sulpholipid K is a shellfish poison extracted from the digestive glands of contaminated mussels. It is probably a metabolite of microalgae ingested by the mussels and concentrated in their gut. Carreira and co-workers report the first diastereoselective synthesis of a polychlorinated sulpholipid which also confirms the assigned stereochemistry.