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Synfacts 2009(9): 0949-0949  
DOI: 10.1055/s-0029-1217614
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Lysergic Acid Methyl Ester

Contributor(s): Philip Kocienski
T. Kurokawa, M. Isomura, H. Tokuyama, T. Fukuyama*
University of Tokyo and Tohoku University, Sendai, Japan
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Publication History

Publication Date:
21 August 2009 (online)

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Significance

A noteworthy step in the Fukuyama synthesis of lysergic acid methyl ester was the double cyclization F → G involving an intramolec­ular Heck reaction and an intramolecular arene ami­nation.