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Synfacts 2009(9): 1014-1014
DOI: 10.1055/s-0029-1217671
DOI: 10.1055/s-0029-1217671
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New YorkChiral β-Hydroxy Ethers from Spiroborate Ester Mediated Reductions
K. Huang, M. Ortiz-Marciales*, W. Correa, E. Pomales, X. Y. López
University of Puerto Rico-Humacao, Puerto Rico
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Publikationsverlauf
Publikationsdatum:
21. August 2009 (online)

Significance
β-Hydroxy ethers serve as valuable precursors for many important pharmaceutical compounds. Several enantioselective routes have been developed including ring opening of epoxides catalyzed by salen complexes as well as ring opening of chiral aryl oxiranes. In the present study the authors apply their spiroborate ester 1 to the enantioselective reduction of various ketone ethers to provide the corresponding β-hydroxy ethers in excellent yields and enantiomeric ratios.