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Synfacts 2009(9): 1018-1018  
DOI: 10.1055/s-0029-1217693
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Cu-Catalyzed Aerobic Oxidative Coupling of Alkynes to H-Phosphonates

Contributor(s): Paul Knochel, Andreas J. Wagner
Y. Gao, G. Wang, L. Chen, P. Xu, Y. Zhao*, Y. Zhou, L.-B. Han*
Xiamen University and Tsinghua University, Beijing, P. R. of China and National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan
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Publikationsdatum:
21. August 2009 (online)

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Significance

A Sonogashira-style reaction of terminal acetylenes with dialkyl phosphonates under copper catalysis and aerobic conditions is reported. A wide range of functional groups is tolerated and the alkynylated phosphonates are obtained in excellent yields.