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Synfacts 2009(9): 1020-1020
DOI: 10.1055/s-0029-1217698
DOI: 10.1055/s-0029-1217698
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
2-Pyrazol-5-ylaniline as ortho-Directing Agent for Arylboronic Acids in C-H Silylation
H. Ihara, M. Suginome*
Kyoto University, Japan
Further Information
Publication History
Publication Date:
21 August 2009 (online)
Significance
2-Pyrazol-5-ylaniline (pza-H2) was found to be an effective ortho-directing agent for arylboronic acids in ruthenium-catalyzed aromatic C-H silylations. The pza ligand can be easily attached and detached from the boronic acid. Silylation takes place regioselectively at the less sterically hindered ortho-position.