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Synfacts 2009(10): 1138-1138  
DOI: 10.1055/s-0029-1217891
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Alkylation of Sulfonamides with Alcohols

Contributor(s): Paul Knochel, Tobias Thaler
F. Shi*, M. K. Tse, X. Cui, D. Gördes, D. Michalik, K. Thurow, Y. Deng, M. Beller*
Lanzhou Institute of Chemical Physics, P. R. of China; Leibniz-Institut für Katalyse e.V. an der Universität Rostock and Universität Rostock, Germany
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Publication History

Publication Date:
22 September 2009 (online)

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Significance

A novel copper-catalyzed alkylation of sulfonamides using alcohols is reported. This economic, highly atom-efficient method could be applied to a broad range of variously substituted sulfonamides. It proceeds best with benzylic alcohols and several functional groups are tolerated.