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Synthesis 2010(7): 1217-1222
DOI: 10.1055/s-0029-1218694
DOI: 10.1055/s-0029-1218694
FEATUREARTICLE
© Georg Thieme Verlag
Stuttgart ˙ New York
A Concise Synthesis of (-)-(3S,6R)-3,6-Dihydroxy-10-methylundecanoic Acid Using a Cross-Metathesis Approach
Further Information
Received
25 January 2010
Publication Date:
12 March 2010 (online)
Publication History
Publication Date:
12 March 2010 (online)
Abstract
A new synthesis of (-)-(3S,6R)-3,6-dihydroxy-10-methylundecanoic acid, a β-hydroxy carboxylic acid, has been accomplished using a cross-metathesis reaction between two terminal olefin intermediates as the key step.
Key words
β-hydroxy acid - cross-metathesis - Jacobsen’s kinetic resolution - TMSI
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