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Synfacts 2010(2): 0134-0134  
DOI: 10.1055/s-0029-1219033
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Formal Synthesis of (+)-Phoslactomycin B

Contributor(s): Philip Kocienski
S. M. Sarkar, E. N. Wanzala, S. Shibahara, K. Takahashi, J. Ishihara, S. Hatakeyama*
Nagasaki University, Japan
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Publikationsdatum:
21. Januar 2010 (online)

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Significance

Phoslactomycin B is a Strepto­myces metabolite whose antitumor activity is a consequence of its selective and potent inhibition of protein serine/threonine phosphatase. A salient feature of the synthesis is an asymmetric Baylis-Hillman reaction mediated by β-isocupreidine (C).