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Synfacts 2010(2): 0214-0214  
DOI: 10.1055/s-0029-1219057
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Pd(II)-Catalyzed ortho-Hydroxylation of Benzoic Acids with 1 atm O2 or Air

Contributor(s): Paul Knochel, Andrei Gavryushin
Y.-H. Zhang, J.-Q. Yu*
The Scripps Research Institute, La Jolla, USA
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Publication History

Publication Date:
21 January 2010 (online)

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Significance

Activation of inert C-H bonds is an important task in organic synthesis. Highly selective Pd-catalyzed ortho-hydroxylation of potassium benzoates using O2 as an oxidant gives good to excellent yields of substituted salicylic acid salts under non-acidic conditions, offering also excellent functional group compatibility.