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Synfacts 2010(2): 0194-0194  
DOI: 10.1055/s-0029-1219145
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of C3*-TunePhos Chiral Ligands and Their Application in Hydrogenation

Contributor(s): Mark Lautens, Chit Tsui
X. Sun, W. Li, G. Hou, L. Zhou, X. Zhang*
The State University of New Jersey, Piscataway, USA and Northwest A&F University, Shaanxi, P. R. of China
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Publication History

Publication Date:
21 January 2010 (online)

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Significance

C 2-Symmetric binaphthyl- or biphenyl-bridged diphosphine ligands BINAP, MeO-­BIPHEP, SEGPHOS, P-Phos and their analogues are well known as highly efficient chiral ligands for a variety of transition-metal-catalyzed asymmetric transformations. The authors report a diastereoselective synthesis of a series of C3*-TunePhos chiral diphosphine ligands. The synthetic utility of these ligands was explored for the ruthenium-­catalyzed asymmetric hydrogenation of β-keto ­esters and excellent ee values were achieved.