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Synfacts 2010(4): 0383-0383  
DOI: 10.1055/s-0029-1219450
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (+)-Isatisine A

Contributor(s): Steven V. Ley, David J. France
A. Karadeolian, M. A. Kerr*
The University of Western Ontario, London, Canada
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Publication History

Publication Date:
22 March 2010 (online)

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Significance

This synthesis of non-natural (+)-isatisine allowed for rigorous assignment of its absolute configuration. Acetonide ent-J has demonstrated anti-HIV-1 activity.