PDF herunterladen
Synfacts 2010(4): 0490-0490  
DOI: 10.1055/s-0029-1219458
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Solid-Phase Synthesis of NOTA-Functionalized Peptides

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada, Hidetoshi Ohta
B. Guérin*, S. Ait-Mohand, M.-C. Tremblay, V. Dumulon-Perreault, P. Fournier, F. Bénard
Université de Sherbrooke and University of British Columbia, Vancouver, Canada
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
22. März 2010 (online)

    Lizenzen und Reprints

Significance

Solid-phase functionalization of peptides at their N-terminal positions or the lysine side chains with 1,4,7-triazacyclononane-N,N′,N′′-triacetic acid (NOTA) for positron emission tomography (PET) imaging was described. Thus, the NOTA-functionalized peptides 1 and 2 were prepared from PS-PEG resin through Fmoc-based solid-phase peptide synthesis (SPPS), bromo­acetylation, macrocycle introduction, alkylation with tert-butyl 2-bromoacetate, deprotection, and cleavage from the solid support.