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Synfacts 2010(4): 0379-0379  
DOI: 10.1055/s-0029-1219484
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Arterolane and Analogues

Contributor(s): Philip Kocienski
J. L. Vennerstrom et al.*
University of Nebraska Medical Center, Omaha, USA; Monash University, Parkville, Australia; Swiss Tropical Institute, Basilea Pharmaceutica and F. Hofmann-La Roche, Basel, Switzerland
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Publikationsdatum:
22. März 2010 (online)

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Significance

Arterolane maleate together with piperaquine phosphate is in phase III clinical trials for the treatment of malaria. Arterolane is a stable synthetic ozonide generated by a stereoselective 1,3-dipolar cycloaddition of the carbonyl ylide C to the cyclohexanone B.