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Synfacts 2010(4): 0431-0431  
DOI: 10.1055/s-0029-1219627
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Rhodium-Catalyzed Enantioselective Hydroamination of Alkenes

Contributor(s): Hisashi Yamamoto, Jiajing Tan
X. Shen, S. L. Buchwald*
Massachusetts Institute of Technology, Cambridge, USA
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Publikationsverlauf

Publikationsdatum:
22. März 2010 (online)

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Significance

The authors report the first example of rhodium-catalyzed asymmetric intramolecular hydroamination of unactivated terminal alkenes. This protocol can be applied to the synthesis of enantioenriched pyrrolidines.

Review: T. E. Müller, K. C. Hultzsch, M. Yus, F. Foubelo, M. Tada Chem. Rev. 2008, 108, 3795-3892.