Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2010(7): 0819-0819
DOI: 10.1055/s-0029-1220050
DOI: 10.1055/s-0029-1220050
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Zinc(II)-Catalyzed Grignard Additions to Ketones with RMgBr and RMgI
M. Hatano, O. Ito, S. Suzuki, K. Ishihara*
Nagoya University, Japan
Further Information
Publication History
Publication Date:
22 June 2010 (online)
Significance
Highly efficient alkylations and arylations of ketones with Grignard reagents (RMgBr and RMgI) have been developed using catalytic amounts of ZnCl2, TMSCH2MgCl, and stoichiometric amounts of LiCl. Tertiary alcohols were obtained in good to excellent yields with high chemoselectivity; while minimizing undesired side products were produced by reduction and enolization.