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Synfacts 2010(7): 0821-0821
DOI: 10.1055/s-0029-1220051
DOI: 10.1055/s-0029-1220051
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Transition-Metal-Free Amination of Aryl Grignard Reagents
T. Hatakeyama, Y. Yoshimoto, S. K. Ghorai, M. Nakamura*
Kyoto University, Uji, Japan
Further Information
Publication History
Publication Date:
22 June 2010 (online)
Significance
In the presence of N,N,N′,N′-tetramethylethylenediamine (TMEDA) as an additive, easily prepared and handled N-chloroamines react with aryl and heteroaryl Grignard reagents at low temperatures giving a variety of aryl amines in good to excellent yields. Functional groups, such as ester and nitrile, are compatible under these reaction conditions.