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Synfacts 2010(7): 0781-0781
DOI: 10.1055/s-0029-1220086
DOI: 10.1055/s-0029-1220086
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Homoallylic Alcohols from Simple Terminal Alkynes
B. Dutta, N. Gilboa, I. Marek*
Technion - Israel Institute of Technology, Haifa, Israel
Further Information
Publication History
Publication Date:
22 June 2010 (online)
Significance
Building upon previous work (J. P. Das, H. Chechik, I. Marek Nat. Chem. 2009, 1, 128) the authors report on a strategy for the diastereoselective preparation of allyl alcohols bearing an all-carbon quaternary center from simple terminal alkynes. Functionalized alkynes bearing directing groups were previously employed in order to control any metalotropic equilibration of the allylmetal species, but the new strategy works with simple terminal alkynes.